Shouldn't it say "Downstream Caches" instead of "Upstream Caches"?
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This section in the document on Django's cache framework mentions that, in addition to the caching provided by Django, other cache systems exist between the user and one's server that may intercept the request; ISP and browser caches are given as examples. From the point of view of the Django-based backend, all those caches are located downstream (i.e., in the direction from server to client). The document, however, refers to them as "upstream".
From the client's point of view, they would indeed be "upstream"—but then again, so would the Django cache :)
For comparison, here is an example of usage of "downstream cache".