Running Django on ​ PyPy boils down to installing both and running Django with pypy instead of python.

Download a ​ PyPy binary from ​http://pypy.org/download.html and follow the install instructions there.

Run Django the usual way with ​ PyPy:

pypy ./manage.py syncdb
pypy ./manage.py runserver

​ PyPy ​runs the templating engine faster than CPython, but so far DB access is slower for some drivers.

Some C-based DB drivers don't work with ​ PyPy. See the ​ Compatibility Wiki for an overview of what works.