You can run Django on PyPy, and it appears to be running reasonably well. By Django version 1.0 the current issues should have been resolved. For now you can get a project like Pinax from Django Hotclub up and running with a bit of extra work. Check out PyPy svn co http://codespeak.net/svn/pypy/dist pypy-dist For Mac: Install Developer Tools Install MacPorts Install libffi Build pypy-c Magic translation command (example): ./translate.py --thread --gc=hybrid targetpypystandalone --faassen --allworkingmodules --oldstyle Check out Django Do a subversion checkout of django trunk. Or get version 1.0 that has the signals speedup (ticket 6814) Or if ticket 6814 is not in yet, apply patch ticket 6857 (http://code.djangoproject.com/ticket/6857) Python 2.4 Django only requires Python 2.3. But, be aware that many popular django applications depend on Python 2.5 runtime lib. * elementtree (from xml.etree import cElementTree as ElementTree) python-openid yadis gdata * hashlib python-openid gravatar Make a link to pypy-c in /usr/shared/bin pypy-c ./manage.py runserver --noreload